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Use in pregnancy: Glipizide GITS was found to be mildly fetotoxic in rat reproductive studies. No teratogenic effects were found in rat or rabbit studies.
Glucotrol XL should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Because recent information suggests that abnormal blood glucose levels during pregnancy are associated with a higher incidence of congenital abnormalities, many exports recommend that insulin be used during pregnancy to maintain blood glucose levels as close to normal as possible.
Prolonged severe hypoglycemia (4-10 days) has been reported in neonates born to mother who were receiving a sulfonylurea drug at the time of delivery. If glipizide GITS is used during pregnancy, it should be discontinued at least 1 month before the expected delivery date and other therapies instituted to maintain blood glucose levels as close to normal as possible.
Use in lactation: Although it is not known whether glipizide GITS is excreted in human milk, some sulfonylurea drugs are known to be excreted in human milk. Because the potential for hypoglycemia in nursing infants may exist, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. If the drug is discontinued and if diet alone is inadequate for controlling blood glucose, insulin therapy should be considered.
